Mentor: Michael Wendt, PhD

My Research:

My research seeks to better understand how signaling pathways and structural changes within the genome enable breast cancer cells to metastasize, undergo de-differentiation programs, and acquire resistance to targeted drug treatment. By integrating experimental and computational methodologies, my work aims to identify cellular targets that can be leveraged to develop more effective, durable therapies for patients with breast cancer.  

Publication:

 Pascetti E, Floren M, Fernandes TDS, Anastasio C, Doyle L, Gillette J. Tetraspanin CD82 regulates Transforming Growth Factor β signaling in Hematopoietic Stem and Progenitor Cells. Mol Biol Cell. 2025 May 28:mbcE24100474. doi: 10.1091/mbc.E24-10-0474. PMID: 40434872.

Presentations:

• October 2025, Doyle L, Wendt M. Oral Presentation:  “Deciphering the Genetic Drivers of Cellular Plasticity in HER2+ Breast Cancer”. University of Iowa Metastasis Research Group, Iowa City, IA, October 16, 2025.
• May 2025.  Poster presentation: Doyle L, Wendt M. "Investigating Cross-talk Between the HER2/FGFR1 Signaling Axes in Metastatic Breast Cancer", The 10th Annual Midwest Tumor Microenvironment Conference, Minneapolis, MN, May 19-21, 2025
• February 2025. Oral presentation: Doyle L. “Investigating Cross-talk Between the HER2/FGFR1 Signaling Axes in Metastatic Breast Cancer”. University of Iowa MSTP Data Blitz, Iowa City, IA, February 19, 2025
• August 2022. Oral presentation: Doyle L, Dupuy A. Oral presentation: “Sleeping Beauty as a novel screening tool for identifying mechanisms of Venetoclax Resistance in Acute Myeloid Leukemia”. University of Iowa MSTP Retreat, Iowa City, IA, August 3-4, 2022
• September 2021. Doyle L, Houtman J. Oral presentation: “Mechanism of GRB2 Nuclear Localization in T-Cells", The University of Iowa Medical Student Research Conference, Iowa City, IA, September 15, 2021.
• August 2021. Poster presentation: “Mechanism of Grb2 Nuclear Localization in T-Cells”. The University of Iowa 

Award:

2021 UI William Johnson Award for Research in Microbiology and Immunology

Service:

Committee Member, University of Iowa MSTP Student Advisory Council

Committee Member, Holden Comprehensive Cancer Center Office of Workforce Access and Advancement.