Mentors: Joseph Cullen, MD and Michael Henry, PhD

Thesis:

Elucidating mechanisms that enhance metastatic phenotypes through drug and fluid shear stress resistance

Presentations:

2025 AEK (German Cancer Society) International Cancer Congress. "Fluid shear stress enhances metastatic potential and rapidly alters metabolism of circulating tumor cells,"  Berlin, Germany. 

2024 Holden Comprehensive Cancer Center Annual Retreat. "Resistance Mechanisms of Pharmacological Ascorbate in Pancreatic Cancer. (poster)

2024 Annual AACR Conference (posters)

2024 AACR Tumor Microenvironment Regional Conference (oral and poster)

2023 Holden Comprehensive Cancer Center Annual Retreat. "Resistance Mechanisms of Pharmacological Ascorbate in Pancreatic Cancer" (poster)

Publications:

1. Du J, Pope AN, O'Leary BR, Wagner BA, Goswami PC, Buettner GR, et al. The role of mitochondria in pharmacological ascorbate-induced toxicity. Scientific reports. 2022;12(1):22521. PMC9800562
2. O'Leary BR, Kalen AL, Pope AN, Goswami PC, Cullen JJ. Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels. Radiat Res. 2023.