Mentors: Rebecca Dodd, PhD, and Eric Taylor, PhD

Thesis: 

CDKN2A and TP53 loss differentially affect metabolic reprogramming in Malignant Peripheral Nerve Sheath Tumors

Publications:

1. McGivney G, Brockman Q, Borcherding N, Scherer A, Rauckhorst A, Gutierrez W, et al. Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. Sci Adv 2025;11(33). DOI: 10.1126/sciadv.adu2906
2. Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty EA, et al. Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. Clin Cancer Res 2020;26(18):5036-47. PMC7641033
3. Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, et al. Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Genes. 2020;11(5). PMC7288323
4. McGivney GR, et al. Somatic CRISPR tumorigenesis and multi-omic analysis reveal a graded pentose phosphate pathway disruption vulnerability in CDKN2A- and P53-deleted MPNSTs. In review, Science Advances.